Holy Cross College Sta. Rosa, Nueva Ecija, Inc. traces its humble beginnings to 1946 when it was established as Holy Cross Academy by a group of dedicated Catholic educators and community leaders in Santa Rosa, Nueva Ecija. Founded shortly after World War II, the institution was conceived as a response to the pressing need for quality education in the region, particularly one rooted in Christian values and principles.

The school began operations in a modest building with only a handful of students and teachers, offering primary and secondary education. The founders envisioned an institution that would not only provide academic excellence but also nurture the spiritual and moral development of the youth in Santa Rosa and neighboring municipalities.

During these transformative decades, Holy Cross College underwent significant growth and development. The institution expanded its academic offerings to include tertiary education, beginning with teacher education programs that would eventually evolve into a full College of Education. This period saw the construction of additional campus facilities, including modern classrooms, laboratories, and administrative buildings.

The college strengthened its commitment to Catholic education while adapting to the changing educational landscape of the Philippines. Programs were developed in response to community needs, particularly in business administration, teacher education, and later in information technology and healthcare fields.

Entering the 21st century, Holy Cross College embraced technological advancements and educational innovations while maintaining its strong Catholic identity. The institution expanded its program offerings to include Information Technology, Hospitality Management, Criminal Justice Education, and Senior High School programs under the K-12 educational reform.

The college established partnerships with industry leaders, implemented quality assurance systems, and engaged in community extension programs that extended its mission beyond the campus. The establishment of the Graduate School marked another milestone in the institution's commitment to lifelong learning and advanced education.

As Holy Cross College Sta. Rosa, N.E., Inc. looks toward the future, it remains committed to its founding mission while adapting to the changing educational landscape. The institution continues to develop innovative programs, enhance its facilities, and adopt modern teaching methodologies to prepare students for the challenges and opportunities of the 21st century.

With a firm foundation in Catholic education and a forward-looking perspective, Holy Cross College is poised to continue its legacy of excellence for generations to come. The story that began in 1946 continues to be written by each student, faculty member, administrator, and alumnus who becomes part of the Holy Cross family.